Scientific Publications 2015 [View all on PubMed]

1. Agnandji ST, Fernandes JF, Bache EB, Ramharter M. Clinical development of RTS,S/AS malaria vaccine: a systematic review of clinical Phase I-III trials. Future Microbiol. 2015;10(10):1553-78. [Abstract]
2. Ajua A, Lell B, Agnandji ST, Asante KP, Owusu-Agyei S, Mwangoka G, Mpina M, Salim N, Tanner M, Abdulla S, Vekemans J, Jongert E, Lievens M, Cambron P, Ockenhouse CF, Kremsner PG, Mordmüller B. The effect of immunization schedule with the malaria vaccine candidate RTS,S/AS01E on protective efficacy and anti-circumsporozoite protein antibody avidity in African infants. Malar J. 2015 Feb 13;14:72. [Abstract] [Free Full Article]
3. Ateba-Ngoa U, Adegnika AA, Zinsou JF, Kassa Kassa RF, Smits H, Massinga-Loembe M, Mordmüller B, Kremsner PG, Yazdanbakhsh M. Cytokine and chemokine profile of the innate and adaptive immune response of Schistosoma haematobium and Plasmodium falciparum single and co-infected school-aged children from an endemic area of Lambaréné, Gabon. Malar J. 2015 Feb 25. 2015 Feb 25;14:94. [Abstract] [Free Full Article]
4. Ayyoub A, Methaneethorn J, Ramharter M, Djimde AA, Tekete M, Duparc S, Borghini-Fuhrer I, Shin JS, Fleckenstein L. Population Pharmacokinetics of Pyronaridine in Pediatric Malaria Patients. Antimicrob Agents Chemother. 2015 Dec. 2015 Dec 14;60(3):1450-8. [Abstract] [Free Full Article]
5. Belard S, Toepfner N, Capan-Melser M, Mombo-Ngoma G, Zoleko-Manego R, Groger M, Matsiegui PB, Agnandji ST, Adegnika AA, González R, Kremsner PG, Menendez C, Ramharter M, Berner R. Streptococcus agalactiae Serotype Distribution and Antimicrobial Susceptibility in Pregnant Women in Gabon, Central Africa. Sci Rep. 2015 Nov 25. 2015 Nov 25;5:17281. [Abstract] [Free Full Article]
6. Bélard S, Janssen S, Osbak KK, Adegnika AA, Ondounda M, Grobusch MP. Limited access to drugs for resistant tuberculosis: a call to action. J Public Health (Oxf). 2015 Dec;37(4):691-3. [Abstract]
7. Bélard S, Toepfner N, Arnold B, Alabi AS, Berner R. β-Hemolytic streptococcal throat carriage and tonsillopharyngitis: a cross-sectional prevalence study in Gabon, Central Africa. Infection. 2015 Apr;43(2):177-83. [Abstract]
8. Blumentrath CG, Grobusch MP, Matsiégui PB, Pahlke F, Zoleko-Manego R, Nzenze-Aféne S, Mabicka B, Sanguinetti M, Kremsner PG, Schaumburg F. Classification of Rhinoentomophthoromycosis into Atypical, Early, Intermediate, and Late Disease: A Proposal. PLoS Negl Trop Dis. 2015 Oct 1;9(10):e0003984. [Abstract] [Free Full Article]
9. Brückner S, Agnandji ST, Berberich S, Bache E, Fernandes JF, Schweiger B, Massinga Loembe M, Engleitner T, Lell B, Mordmüller B, Adegnika AA, Yazdanbakhsh M, Kremsner PG, Esen M. Effect of Antihelminthic Treatment on Vaccine Immunogenicity to a Seasonal Influenza Vaccine in Primary School Children in Gabon: A Randomized Placebo-Controlled Trial. PLoS Negl Trop Dis. 2015 Jun 8;9(6):e0003768. [Abstract] [Free Full Article]
10. Capan-Melser M, Mombo-Ngoma G, Akerey-Diop D, Basra A, Manego-Zoleko R, Würbel H, Lötsch F, Groger M, Skoll M, Schwing J, Schipulle U, Matsiegui PB, González R, Menendez C, Kremsner PG, Adegnika AA, Agnandji ST, Ramharter M. Epidemiology of Human Herpes Virus 8 in Pregnant Women and their Newborns--A cross-sectional delivery survey in Central Gabon. Int J Infect Dis. 2015 Oct;39:16-9. [Abstract]
11. Capan-Melser M, Mombo Ngoma G, Akerey-Diop D, Basra A, Würbel H, Groger M, Mackanga JR, Zoleko-Manego R, Schipulle U, Schwing J, Lötsch F, Rehman K, Matsiegui PB, Agnandji ST, Adegnika AA, Bélard S, González R, Kremsner PG, Menendez C, Ramharter M. Evaluation of intermittent preventive treatment of malaria against group B Streptococcus colonization in pregnant women: a nested analysis of a randomized controlled clinical trial of sulfadoxine/pyrimethamine versus mefloquine. J Antimicrob Chemother. 2015;70(6):1898-902. [Abstract]
12. Ehrhardt J, Alabi AS, Kuczius T, Tsombeng FF, Becker K, Kremsner PG, Schaumburg F, Esen M. Population structure of Legionella spp. from environmental samples in Gabon, 2013. Infect Genet Evol. 2015 Jul;33:299-303 [Abstract]
13. Fernandes JF, Lell B, Agnandji ST, Obiang RM, Bassat Q, Kremsner PG, Mordmüller B, Grobusch MP. Fosmidomycin as an antimalarial drug: a meta-analysis of clinical trials. Future Microbiol. 2015;10(8):1375-90. [Abstract]
14. Gabor JJ, Schwarz NG, Esen M, Kremsner PG, Grobusch MP. Influenza A and Parvovirus B19 Seropositivity Rates in Gabonese Infants. Am J Trop Med Hyg. 2015 Aug;93(2):407-9. [Abstract] [Free Full Article]
15. Goovaerts O, Jennes W, Massinga-Loembé M, Ondoa P, Ceulemans A, Vereecken C, Worodria W, Mayanja-Kizza H, Colebunders R, Kestens L; TB-IRIS Study Group. Lower Pre-Treatment T Cell Activation in Early- and Late-Onset Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome. PLoS One. 2015 Jul 24. 2015 Jul 24;10(7):e0133924. [Abstract] [Free Full Article]
16. Held J, Supan C, Salazar CL, Tinto H, Bonkian LN, Nahum A, Moulero B, Sié A, Coulibaly B, Sirima SB, Siribie M, Otsyula N, Otieno L, Abdallah AM, Kimutai R, Bouyou-Akotet M, Kombila M, Koiwai K, Cantalloube C, Din-Bell C, Djeriou E, Waitumbi J, Mordmüller B, Ter-Minassian D, Lell B, Kremsner PG. Ferroquine and artesunate in African adults and children with Plasmodium falciparum malaria: a phase 2, multicentre, randomised, double-blind, dose-ranging, non-inferiority study. Lancet Infect Dis. 2015 Dec;15(12):1409-19 [Abstract]
17. Huson MA, Zeerleder SS, van Mierlo G, Wouters D, Grobusch MP, van der Poll T. HIV infection is associated with elevated nucleosomes in asymptomatic patients and during sepsis or malaria. J Infect. 2015 Aug;71(2):266-9. [Abstract]
18. Huson MA, Wouters D, van Mierlo G, Grobusch MP, Zeerleder SS, van der Poll T. HIV Coinfection Enhances Complement Activation During Sepsis. J Infect Dis. 2015 Aug 1;212(3):474-83. [Abstract]
19. Janssen S, Wieten RW, Stolp S, Cremers AL, Rossatanga EG, Klipstein-Grobusch K, Belard S, Grobusch MP. Factors Associated with Retention to Care in an HIV Clinic in Gabon, Central Africa. PLoS One. 2015 Oct 16;10(10):e0140746. [Abstract] [Free Full Article]
20. Janssen S, Hermans S, Knap M, Moekotte A, Rossatanga EG, Adegnika AA, Bélard S, Hänscheid T, Grobusch MP. Impact of Anti-Retroviral Treatment and Cotrimoxazole Prophylaxis on Helminth Infections in HIV-Infected Patients in Lambaréné, Gabon. PLoS Negl Trop Dis. 2015 May 20;9(5):e0003769. [Abstract] [Free Full Article]
21. Kraef C, Alabi AS, Peters G, Becker K, Kremsner PG, Rossatanga EG, Mellmann A, Grobusch MP, Zanger P, Schaumburg F. Co-detection of Panton-Valentine leukocidin encoding genes and cotrimoxazole resistance in Staphylococcus aureus in Gabon: implications for HIV-patients' care. Front Microbiol. 2015 Feb 5;6:60. [Abstract] [Free Full Article]
22. Medaglini D, Harandi AM, Ottenhoff TH, Siegrist CA; VSV-Ebovac Consortium. Ebola vaccine R&D: Filling the knowledge gaps. Sci Transl Med. 2015 Dec 9;7(317):317ps24. [Abstract]
23. Mombo-Ngoma G, Mackanga JR, Basra A, Capan M, Manego RZ, Adegnika AA, Lötsch F, Yazdanbakhsh M, González R, Menendez C, Mabika B, Matsiegui PB, Kremsner PG, Ramharter M. Loa loa Infection in Pregnant Women, Gabon. Emerg Infect Dis. 2015 May;21(5):899a-901. [Abstract] [Free Full Article]
24. Neafsey DE, Juraska M, Bedford T, Benkeser D, Valim C, Griggs A, Lievens M, Abdulla S, Adjei S, Agbenyega T, Agnandji ST, Aide P, Anderson S, Ansong D, Aponte JJ, Asante KP, Bejon P, Birkett AJ, Bruls M, Connolly KM, D'Alessandro U, Dobaño C, Gesase S, Greenwood B, Grimsby J, Tinto H, Hamel MJ, Hoffman I, Kamthunzi P, Kariuki S, Kremsner PG, Leach A, Lell B, Lennon NJ, Lusingu J, Marsh K, Martinson F, Molel JT, Moss EL, Njuguna P, Ockenhouse CF, Ogutu BR, Otieno W, Otieno L, Otieno K, Owusu-Agyei S, Park DJ, Pellé K, Robbins D, Russ C, Ryan EM, Sacarlal J, Sogoloff B, Sorgho H, Tanner M, Theander T, Valea I, Volkman SK, Yu Q, Lapierre D, Birren BW, Gilbert PB, Wirth DF. Genetic Diversity and Protective Efficacy of the RTS,S/AS01 Malaria Vaccine. N Engl J Med. 2015 Nov 19;373(21):2025-37. [Abstract] [Free Full Article]
25. Nguetse CN, Kremsner PG, Velavan TP. FOXO3A regulatory polymorphism and susceptibility to severe malaria in Gabonese children. Immunogenetics. 2015 Feb;67(2):67-71. [Abstract]
26. Rebelo M, Tempera C, Fernandes JF, Grobusch MP, Hänscheid T. Assessing anti-malarial drug effects ex vivo using the haemozoin detection assay. Malar J. 2015 Apr 1;14:140. [Abstract] [Free Full Article]
27. Rolling T, Agbenyega T, Krishna S, Kremsner PG, Cramer JP. Delayed haemolysis after artesunate treatment of severe malaria - review of the literature and perspective. Travel Med Infect Dis. 2015 Mar-Apr;13(2):143-9. [Abstract]
28. RTS,S Clinical Trials Partnership. Efficacy and safety of RTS,S/AS01 malaria vaccine with or without a booster dose in infants and children in Africa: final results of a phase 3, individually randomised, controlled trial. Lancet. 2015 Jul 4;386(9988):31-45. [Abstract]
29. Schaumburg F, Alabi AS, Kaba H, Lell B, Becker K, Grobusch MP, Kremsner PG, Mellmann A. Molecular characterization of Shigella spp. from patients in Gabon 2011-2013. Trans R Soc Trop Med Hyg. 2015 Apr;109(4):275-9. [Abstract]
30. Schaumburg F, Pauly M, Anoh E, Mossoun A, Wiersma L, Schubert G, Flammen A, Alabi AS, Muyembe-Tamfum JJ, Grobusch MP, Karhemere S, Akoua-Koffi C, Couacy-Hymann E, Kremsner PG, Mellmann A, Becker K, Leendertz FH, Peters G. Staphylococcus aureus complex from animals and humans in three remote African regions. Clin Microbiol Infect. 2015 Apr;21(4):345.e1-8. [Abstract]
31. Schmiedel Y, Mombo-Ngoma G, Labuda LA, Janse JJ, de Gier B, Adegnika AA, Issifou S, Kremsner PG, Smits HH, Yazdanbakhsh M. CD4+CD25hiFOXP3+ Regulatory T Cells and Cytokine Responses in Human Schistosomiasis before and after Treatment with Praziquantel. PLoS Negl Trop Dis. 2015 Aug 20;9(8):e0003995 [Abstract] [Free Full Article]
32. Schmutzhard J, Lackner P, Helbok R, Hurth HV, Aregger FC, Muigg V, Kegele J, Bunk S, Oberhammer L, Fischer N, Pinggera L, Otieno A, Ogutu B, Agbenyega T, Ansong D, Adegnika AA, Issifou S, Zorowka P, Krishna S, Mordmüller B, Schmutzhard E, Kremsner P. Severe malaria in children leads to a significant impairment of transitory otoacoustic emissions--a prospective multicenter cohort study. BMC Med. 2015 May 28;13:125 [Abstract] [Free Full Article]
33. Sicuri E, Fernandes S, Macete E, González R, Mombo-Ngoma G, Massougbodgi A, Abdulla S, Kuwawenaruwa A, Katana A, Desai M, Cot M, Ramharter M, Kremsner P, Slustker L, Aponte J, Hanson K, Menéndez C. Economic evaluation of an alternative drug to sulfadoxine-pyrimethamine as intermittent preventive treatment of malaria in pregnancy. PLoS One. 2015 Apr 27;10(4):e0125072. [Abstract] [Free Full Article]
34. Visser BJ, Meerveld-Gerrits J, Kroon D, Mougoula J, Vingerling R, Bache E, Boersma J, van Vugt M, Agnandji ST, Kaur H, Grobusch MP. Assessing the quality of anti-malarial drugs from Gabonese pharmacies using the MiniLab®: a field study. 2015 Jul .Malar J. 2015 Jul 15;14:273. [Abstract] [Free Full Article]
35. White MT, Verity R, Griffin JT, Asante KP, Owusu-Agyei S, Greenwood B,Drakeley C, Gesase S, Lusingu J, Ansong D, Adjei S, Agbenyega T, Ogutu B, Otieno L, Otieno W, Agnandji ST, Lell B, Kremsner P, Hoffman I, Martinson F, Kamthunzu P, Tinto H, Valea I, Sorgho H, Oneko M, Otieno K, Hamel MJ, Salim N, Mtoro A, Abdulla S, Aide P, Sacarlal J, Aponte JJ, Njuguna P, Marsh K, Bejon P, Riley EM, Ghani AC. Immunogenicity of the RTS,S/AS01 malaria vaccine and implications for duration of vaccine efficacy: secondary analysis of data from a phase 3 randomised controlled trial. Lancet Infect Dis. 2015 Dec;15(12):1450-8. [Abstract] [Free Full Article]
36. Wiersinga WJ, Birnie E, Weehuizen TA, Alabi AS, Huson MA, Huis in 't Veld RA, Mabala HK, Adzoda GK, Raczynski-Henk Y, Esen M, Lell B, Kremsner PG, Visser CE, Wuthiekanun V, Peacock SJ, van der Ende A, Limmathurotsakul D, Grobusch MP. Clinical, environmental, and serologic surveillance studies of melioidosis in Gabon, 2012-2013. Emerg Infect Dis. 2015 Jan;21(1):40-7. [Abstract] [Free Full Article]