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Publications scientifiques 2020 [View all on PubMed]

  1. Abe H, Ushijima Y, Bikangui R, Loembe MM, Agnandji ST, de Vries SG, Grobusch MP, Lell B, Yasuda J. Ongoing evolution of hepatitis B virus during viremia in patients with febrile in Central Africa. J Med Virol. 2020 Feb. [Abstract]
  2. Abe H, Ushijima Y, Bikangui R, Ondo GN, Zadeh VR, Pemba CM, Mpingabo PI, Igasaki Y, de Vries SG, Grobusch MP, Loembe MM, Agnandji ST, Lell B, Yasuda J. First evidence for continuous circulation of hepatitis A virus subgenotype IIA in Central Africa. J Viral Hepat. 2020 Nov;27.
    [Abstract] [Free Full Article]
  3. Abe H, Ushijima Y, Loembe MM, Bikangui R, Nguema-Ondo G, Mpingabo PI, Zadeh VR, Pemba CM, Kurosaki Y, Igasaki Y, de Vries SG, Grobusch MP, Agnandji ST, Lell B, Yasuda J. Re-emergence of dengue virus serotype 3 infections in Gabon in 2016-2017, and evidence for the risk of repeated dengue virus infections. Int J Infect Dis. 2020 Feb. [Abstract]
  4. Ackerman H, Ayestaran A, Olola CHO, Jallow M, Agbenyega T, Bojang K, Roberts DJ, Krishna S, Kremsner PG, Newton CR, Taylor T, Valim C, Casals-Pascual C. The effect of blood transfusion on outcomes among African children admitted to hospital with Plasmodium falciparum malaria: a prospective, multicentre observational study. Lancet Haematol. 2020 Nov . [Abstract] [Free Full Article]
  5. Ackerman H, Olola CHO, Krishna S, Roberts DJ, Kremsner PG, Newton CR, Taylor T, Valim C, Casals-Pascual C. Time-to-death is a potential confounder in observational studies of blood transfusion in severe malaria - Authors' reply. Lancet Haematol. 2021 Jan. [Abstract]
  6. Adegbite BR, Edoa JR, Achimi Agbo P, Dejon-Agobé JC, N Essone P, Lotola- Mougeni F, Mbong Ngwese M, Mfoumbi A, Mevyann C, Epola M, Zinsou JF, Honkpehedji YJ, Agnandji ST, Kremsner PG, Alabi AS, Adegnika AA, Grobusch MP. Epidemiological, Mycobacteriological, and Clinical Characteristics of Smoking Pulmonary Tuberculosis Patients, in Lambaréné, Gabon: A Cross-Sectional Study. Am J Trop Med Hyg. 2020 Dec. [Abstract] [Free Full Article]
  7. Adegnika AA, de Vries SG, Zinsou FJ, Honkepehedji YJ, Dejon Agobé JC, Vodonou KG, Bikangui R, Bouyoukou Hounkpatin A, Bache EB, Massinga Loembe M, van Leeuwen R, Molemans M, Kremsner PG, Yazdanbakhsh M, Hotez PJ, Bottazzi ME, Li G, Bethony JM, Diemert DJ, Grobusch MP; HookVac Consortium. Safety and immunogenicity of co-administered hookworm vaccine candidates Na-GST-1 and Na- APR-1 in Gabonese adults: a randomised, controlled, double-blind, phase 1 dose- escalation trial. Lancet Infect Dis. 2021 Feb. [Abstract]
  8. Bache BE, Grobusch MP, Agnandji ST. Safety, immunogenicity and risk-benefit analysis of rVSV-ΔG-ZEBOV-GP (V920) Ebola vaccine in Phase I-III clinical trials across regions. Future Microbiol. 2020 Jan. [Abstract]
  9. Bouwman SA, Zoleko-Manego R, Renner KC, Schmitt EK, Mombo-Ngoma G, Grobusch MP. The early preclinical and clinical development of cipargamin (KAE609), a novel antimalarial compound. Travel Med Infect Dis. 2020 Jul-Aug. [Abstract]
  10. Bretscher MT, Dahal P, Griffin J, Stepniewska K, Bassat Q, Baudin E, D'Alessandro U, Djimde AA, Dorsey G, Espié E, Fofana B, González R, Juma E, Karema C, Lasry E, Lell B, Lima N, Menéndez C, Mombo-Ngoma G, Moreira C, Nikiema F, Ouédraogo JB, Staedke SG, Tinto H, Valea I, Yeka A, Ghani AC, Guerin PJ, Okell LC. The duration of chemoprophylaxis against malaria after treatment with artesunate-amodiaquine and artemether-lumefantrine and the effects of pfmdr1 86Y and pfcrt 76T: a meta-analysis of individual patient data. BMC Med. 2020 Feb.
    [Abstract] [Free Full Article]
  11. Dejon-Agobé JC, Honkpehedji YJ, Zinsou JF, Edoa JR, Adégbitè BR, Mangaboula A, Agnandji ST, Mombo-Ngoma G, Ramharter M, Kremsner PG, Lell B, Grobusch MP, Adegnika AA. Epidemiology of Schistosomiasis and Soil-Transmitted Helminth Coinfections among Schoolchildren Living in Lambaréné, Gabon. Am J Trop Med Hyg. 2020 Jul. [Abstract] [Free Full Article]
  12. Escadafal C, Geis S, Siqueira AM, Agnandji ST, Shimelis T, Tadesse BT, Massinga Loembé M, Harris V, Fernandez-Carballo BL, Macé A, Ongarello S, Rodriguez W, Dittrich S. Bacterial versus non-bacterial infections: a methodology to support use-case-driven product development of diagnostics. BMJ Glob Health. 2020 Oct. [Abstract] [Free Full Article]
  13. Fernandes JF, Held J, Dorn M, Lalremruata A, Schaumburg F, Alabi A, Agbanrin MD, Kokou C, Ben Adande A, Esen M, Eibach D, Adegnika AA, Agnandji ST, Lell B, Eckerle I, Henrichfreise B, Hogan B, May J, Kremsner PG, Grobusch MP, Mordmüller B. Causes of fever in Gabonese children: a cross-sectional hospital-based study. Sci Rep. 2020 Feb 7. [Abstract] [Free Full Article]
  14. Fernandes JF, Laubscher F, Held J, Eckerle I, Docquier M, Grobusch MP, Mordmüller B, Kaiser L, Cordey S. Unbiased metagenomic next-generation sequencing of blood from hospitalized febrile children in Gabon. Emerg Microbes Infect. 2020 Dec;9. [Abstract] [Free Full Article]
  15. Flügge J, Adegnika AA, Honkpehedji YJ, Sandri TL, Askani E, Manouana GP, Massinga Loembe M, Brückner S, Duali M, Strunk J, Mordmüller B, Agnandji ST, Lell B, Kremsner PG, Esen M. Impact of Helminth Infections during Pregnancy on Vaccine Immunogenicity in Gabonese Infants. Vaccines (Basel). 2020 Jul 11. [Abstract] [Free Full Article]
  16. Goovaerts O, Massinga-Loembé M, Ondoa P, Ceulemans A, Worodria W, Mayanja- Kizza H, Colebunders R, Kestens L; TB-IRIS Study Group. Lack of elevated pre-ART elastase-ANCA levels in patients developing TB-IRIS. PLoS One. 2020 Dec 31. [Abstract] [Free Full Article]
  17. Hoekstra PT, Schwarz NG, Adegnika AA, Andrianarivelo MR, Corstjens PLAM, Rakotoarivelo RA, Rakotozandrindrainy R, Sicuri E, Kreidenweiss A, van Dam GJ; freeBILy consortium. Fast and reliable easy-to-use diagnostics for eliminating bilharzia in young children and mothers: An introduction to the freeBILy project. Acta Trop. 2020 Nov. [Abstract]
  18. Honkpehedji YJ, Adegnika AA, Dejon-Agobe JC, Zinsou JF, Mba RB, Gerstenberg J, Rakotozandrindrainy R, Rakotoarivelo RA, Rasamoelina T, Sicuri E, Schwarz NG, Corstjens PLAM, Hoekstra PT, van Dam GJ, Kreidenweiss A; freeBILy Consortium. Prospective, observational study to assess the performance of CAA measurement as a diagnostic tool for the detection of Schistosoma haematobium infections in pregnant women and their child in Lambaréné, Gabon: study protocol of the freeBILy clinical trial in Gabon. BMC Infect Dis. 2020 Sep 29. [Abstract] [Free Full Article]
  19. Huijben S, Macete E, Mombo-Ngoma G, Ramharter M, Kariuki S, Desai M, Shi YP, Mwangoka G, Massougbodji A, Cot M, Ndam NT, Uberegui E, Gupta H, Cisteró P, Aponte JJ, González R, Menéndez C, Mayor A. Counter-Selection of Antimalarial Resistance Polymorphisms by Intermittent Preventive Treatment in Pregnancy. J Infect Dis. 2020 Jan 2. [Abstract]
  20. Koehne E, Kreidenweiss A, Adegbite BR, Manego RZ, McCall MBB, Mombo-Ngoma G, Adegnika AA, Agnandji ST, Mordmüller B, Held J. In vitro activity of eravacycline, a novel synthetic halogenated tetracycline, against the malaria parasite Plasmodium falciparum. J Glob Antimicrob Resist. 2021 Mar. [Abstract]
  21. Labuda LA, Adegnika AA, Rosa BA, Martin J, Ateba-Ngoa U, Amoah AS, Lima HM, Meurs L, Mbow M, Manurung MD, Zinsou JF, Smits HH, Kremsner PG, Mitreva M, Yazdanbakhsh M. A Praziquantel Treatment Study of Immune and Transcriptome Profiles in Schistosoma haematobium-Infected Gabonese Schoolchildren. J Infect Dis. 2020 Nov 13. [Abstract] [Free Full Article]
  22. Lalremruata A, Nguyen TT, McCall MBB, Mombo-Ngoma G, Agnandji ST, Adegnika AA, Lell B, Ramharter M, Hoffman SL, Kremsner PG, Mordmüller B. Recombinase Polymerase Amplification and Lateral Flow Assay for Ultrasensitive Detection of Low-Density Plasmodium falciparum Infection from Controlled Human Malaria Infection Studies and Naturally Acquired Infections. J Clin Microbiol. 2020 Apr 23. [Abstract] [Free Full Article]
  23. Manouana GP, Lorenz E, Mbong Ngwese M, Nguema Moure PA, Maiga Ascofaré O, Akenten CW, Amuasi J, Rakotozandrindrainy N, Rakotozandrindrainy R, Mbwana J, Lusingu J, Byrne N, Melhem S, Zinsou JF, Adegbite RB, Hogan B, Winter D, May J, Kremsner PG, Borrmann S, Eibach D, Adegnika AA. Performance of a rapid diagnostic test for the detection of Cryptosporidium spp. in African children admitted to hospital with diarrhea. PLoS Negl Trop Dis. 2020 Jul 13. [Abstract] [Free Full Article]
  24. Matthewman J, Manego RZ, Dimessa Mbadinga LB, Šinkovec H, Völker K, Akinosho M, Haedrich C, Tardif d'Hamonville J, Lell B, Adegnika AA, Ramharter M, Mombo- Ngoma G. A randomized controlled trial comparing the effectiveness of individual versus household treatment for Scabies in Lambaréné, Gabon. PLoS Negl Trop Dis. 2020 Jun 26. [Abstract] [Free Full Article]
  25. Mbong Ngwese M, Prince Manouana G, Nguema Moure PA, Ramharter M, Esen M, Adégnika AA. Diagnostic Techniques of Soil-Transmitted Helminths: Impact on Control Measures. Trop Med Infect Dis. 2020 Jun 5. [Abstract] [Free Full Article]
  26. Mbow M, Lell B, Jochems SP, Cisse B, Mboup S, Dewals BG, Jaye A, Dieye A, Yazdanbakhsh M. COVID-19 in Africa: Dampening the storm? Science. 2020 Aug 7. [Abstract]
  27. Moirongo RM, Lorenz E, Ntinginya NE, Dekker D, Fernandes J, Held J, Lamshöft M, Schaumburg F, Mangu C, Sudi L, Sie A, Souares A, Heinrich N, Wieser A, Mordmüller B, Owusu-Dabo E, Adegnika AA, Coulibaly B, May J, Eibach D. Regional Variation of Extended-Spectrum Beta-Lactamase (ESBL)-Producing Enterobacterales, Fluoroquinolone-Resistant Salmonella enterica and Methicillin-Resistant Staphylococcus aureus Among Febrile Patients in Sub-Saharan Africa. Front Microbiol. 2020 Sep 25. [Abstract] [Free Full Article]
  28. Moncunill G, Scholzen A, Mpina M, Nhabomba A, Hounkpatin AB, Osaba L, Valls R, Campo JJ, Sanz H, Jairoce C, Williams NA, Pasini EM, Arteta D, Maynou J, Palacios L, Duran-Frigola M, Aponte JJ, Kocken CHM, Agnandji ST, Mas JM, Mordmüller B, Daubenberger C, Sauerwein R, Dobaño C. Antigen-stimulated PBMC transcriptional protective signatures for malaria immunization. Sci Transl Med. 2020 May 13. [Abstract]
  29. Mveang Nzoghe A, Essone PN, Leboueny M, Maloupazoa Siawaya AC, Bongho EC, Mvoundza Ndjindji O, Avome Houechenou RM, Agnandji ST, Djoba Siawaya JF. Evidence and implications of pre-existing humoral cross-reactive immunity to SARS-CoV-2. Immun Inflamm Dis. 2021 Mar.
    [Abstract] [Free Full Article]
  30. Nguetse CN, Purington N, Ebel ER, Shakya B, Tetard M, Kremsner PG, Velavan TP, Egan ES. A common polymorphism in the mechanosensitive ion channel PIEZO1 is associated with protection from severe malaria in humans. Proc Natl Acad Sci U S A. 2020 Apr 21. [Abstract] [Free Full Article]
  31. Nkemngo FN, Mugenzi LMJ, Terence E, Niang A, Wondji MJ, Tchoupo M, Nguete ND, Tchapga W, Irving H, Ntabi JDM, Agonhossou R, Boussougou-Sambe TS, Akoton RB, Koukouikila-Koussounda F, Pinilla YT, Ntoumi F, Djogbenou LS, Ghogomu SM, Ndo C, Adegnika AA, Borrmann S, Wondji CS. Multiple insecticide resistance and Plasmodium infection in the principal malaria vectors Anopheles funestus and Anopheles gambiae in a forested locality close to the Yaoundé airport, Cameroon. Wellcome Open Res. 2020 Nov 5. [Abstract] [Free Full Article]
  32. Nouatin O, Ateba Ngoa U, Ibáñez J, Dejon-Agobe JC, Mordmüller B, Edoa JR, Mougeni F, Brückner S, Bouyoukou Hounkpatin A, Esen M, Theisen M, Moutairou K, Hoffman SL, Issifou S, Luty AJF, Loembe MM, Agnandji ST, Lell B, Kremsner PG, Adegnika AA. Effect of immune regulatory pathways after immunization with GMZ2 malaria vaccine candidate in healthy lifelong malaria-exposed adults. Vaccine. 2020 Jun 2. [Abstract] [Free Full Article]
  33. Omar SV, Hillemann D, Pandey S, Merker M, Witt AK, Nadarajan D, Barilar I, Bainomugisa A, Kelly EC, Diel R, Vidanagama DS, Samarasinghe AIP, Cader MR, Götsch U, Lavu E, Alabi A, Schön T, Coulter C, Niemann S, Maurer FP, Ismail NA, Köser CU, Ismail F. Systematic rifampicin resistance errors with Xpert® MTB/RIF Ultra: implications for regulation of genotypic assays. Int J Tuberc Lung Dis. 2020 Dec 1. [Abstract]
  34. Otieno L, Guerra Mendoza Y, Adjei S, Agbenyega T, Agnandji ST, Aide P, Akoo P, Ansong D, Asante KP, Berkley JA, Gesase S, Hamel MJ, Hoffman I, Kaali S, Kamthunzi P, Kariuki S, Kremsner P, Lanaspa M, Lell B, Lievens M, Lusingu J, Malabeja A, Masoud NS, Mtoro AT, Njuguna P, Ofori-Anyinam O, Otieno GA, Otieno W, Owusu-Agyei S, Schuerman L, Sorgho H, Tanner M, Tinto H, Valea I, Vandoolaeghe P, Sacarlal J, Oneko M. Safety and immunogenicity of the RTS,S/AS01 malaria vaccine in infants and children identified as HIV-infected during a randomized trial in sub-Saharan Africa. Vaccine. 2020 Jan 22. [Abstract]
  35. Pallerla SR, Elion Assiana DO, Linh LTK, Cho FN, Meyer CG, Fagbemi KA, Adegnika AA, Beng VP, Achidi EA, Kahunu GM, Bates M, Grobusch MP, Kremsner PG, Ntoumi F, Velavan TP. Pharmacogenetic considerations in the treatment of co- infections with HIV/AIDS, tuberculosis and malaria in Congolese populations of Central Africa. Int J Infect Dis. 2021 Mar. [Abstract]
  36. Remppis J, Verheyden A, Bustinduy AL, Heller T, García-Tardón N, Manouana GP, Obiang R, Adegnika AA, Grobusch MP, Ramharter M, Joekes E, Bélard S. Focused Assessment with Sonography for Urinary Schistosomiasis (FASUS)-pilot evaluation of a simple point-of-care ultrasound protocol and short training program for detecting urinary tract morbidity in highly endemic settings. Trans R Soc Trop Med Hyg. 2020 Jan 6. [Abstract]
  37. Schaumburg F, Flamen A, Ehrhardt J, Alabi AS, van der Linden MPG. Colonization dynamics of Streptococcus pneumoniae in a remote African population: A prospective cohort study. Vaccine. 2020 Jul 22. [Abstract]
  38. Tichkule S, Jex AR, van Oosterhout C, Sannella AR, Krumkamp R, Aldrich C, Maiga-Ascofare O, Dekker D, Lamshöft M, Mbwana J, Rakotozandrindrainy N, Borrmann S, Thye T, Schuldt K, Winter D, Kremsner PG, Oppong K, Manouana P, Mbong M, Gesase S, Minja DTR, Mueller I, Bahlo M, Nader J, May J, Rakotozandrindrain R, Adegnika AA, Lusingu JPA, Amuasi J, Eibach D, Caccio SM. Comparative genomics revealed adaptive admixture in Cryptosporidium hominis in Africa. Microb Genom. 2021 Jan. [Abstract] [Free Full Article]
  39. Veletzky L, Hergeth J, Stelzl DR, Mischlinger J, Manego RZ, Mombo-Ngoma G, McCall MBB, Adegnika AA, Agnandji ST, Metzger WG, Matsiegui PB, Lagler H, Mordmüller B, Budke C, Ramharter M. Burden of disease in Gabon caused by loiasis: a cross-sectional survey. Lancet Infect Dis. 2020 Nov. [Abstract]
  40. Wang J, Xu C, Wong YK, He Y, Adegnika AA, Kremsner PG, Agnandji ST, Sall AA, Liang Z, Qiu C, Liao FL, Jiang T, Krishna S, Tu Y. Preparedness is essential for malaria-endemic regions during the COVID-19 pandemic. Lancet. 2020 Apr 4. [Abstract] [Free Full Article]
  41. Zinsou JF, Janse JJ, Honpkehedji YY, Dejon-Agobé JC, García-Tardón N, Hoekstra PT, Massinga-Loembe M, Corstjens PLAM, van Dam GJ, Giera M, Kremsner PG, Yazdanbakhsh M, Adegnika AA, Guigas B. Schistosoma haematobium infection is associated with lower serum cholesterol levels and improved lipid profile in overweight/obese individuals. PLoS Negl Trop Dis. 2020 Jul 2. [Abstract] [Free Full Article]